Testis Development and Fertility Potential in Boys with Klinefelter Syndrome
نویسندگان
چکیده
منابع مشابه
The feasibility of fertility preservation in adolescents with Klinefelter syndrome.
STUDY QUESTION Is fertility preservation feasible after the onset of puberty in adolescents with Klinefelter syndrome (KS)? SUMMARY ANSWER Fertility preservation counseling should be an integral part of the care of XXY adolescents. Frozen ejaculated or testicular spermatozoa and even frozen immature germ cells can give them the potential to conceive their genetic progeny. However, no biologic...
متن کاملBehavioral and social phenotypes in boys with 47,XYY syndrome or 47,XXY Klinefelter syndrome.
OBJECTIVE To contrast the behavioral and social phenotypes including a screen for autistic behaviors in boys with 47,XYY syndrome (XYY) or 47,XXY Klinefelter syndrome (KS) and controls and investigate the effect of prenatal diagnosis on the phenotype. METHODS Patients included 26 boys with 47,XYY, 82 boys with KS, and 50 control boys (ages 4-15 years). Participants and parents completed a phy...
متن کاملPhenotype and Adverse Quality of Life in Boys with Klinefelter Syndrome.
OBJECTIVES To characterize associations among psychosocial well-being, physical phenotype, and sex hormones in a sample of youth with Klinefelter syndrome (KS). We hypothesized that KS physical traits (phenotype) are associated with adverse psychosocial health measures and that testosterone levels are associated with adverse psychosocial health. STUDY DESIGN Forty-three boys with KS (ages 8-1...
متن کاملFrequency of XY sperm increases with age in fathers of boys with Klinefelter syndrome.
With increasing availability of drugs for impotence and advanced reproductive technologies for the treatment of subfertility, more men are fathering children at advanced ages. We conducted a study of the chromosomal content of sperm of healthy men aged 24-57 years to (a) determine whether father's age was associated with increasing frequencies of aneuploid sperm including XY, disomy X, disomy Y...
متن کاملTesticular function and fertility in men with Klinefelter syndrome: a review.
Klinefelter syndrome, 47,XXY (KS), is the most frequent sex chromosome aberration in males, affecting 1 in 660 newborn boys. The syndrome is characterized by testicular destruction with extensive fibrosis and hyalinization of the seminiferous tubules resulting in small testes, hypergonadotropic hypogonadism, and azoospermia in the majority of cases. Until recently, infertility was considered an...
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ژورنال
عنوان ژورنال: Endocrinology and Metabolism Clinics of North America
سال: 2015
ISSN: 0889-8529
DOI: 10.1016/j.ecl.2015.07.008